Changelog¶

1.0.0 - 2026-10-06¶

Initial public release of COFOLDER.

Bias, Validate, Screen, and Oracle workflows.
Support for Boltz1, Boltz2, Boltz Community, and OpenFold3 backends.
Protein, ligand, DNA, RNA, and backend-specific constraint inputs.
Structural validation, interaction fingerprints, reference-overlap diagnostics, and screening filters and clustering.
Python API with composite Oracle objectives and structure gates.
Structured public outputs with execution and metric provenance.
Installation guides, API documentation, examples, and interactive tutorials.

Development snapshot used for the COFOLDER manuscript. This version is retained as the manuscript reference version.